For enhanced safety, the front and second-row seat shoulder belts of the Hyundai Santa Fe Hybrid have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Nissan Murano doesn’t offer pretensioners for its rear seat belts.
Both the Santa Fe Hybrid and Murano have child safety locks to prevent children from opening the rear doors. The Santa Fe Hybrid has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Murano’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
When descending a steep, off-road slope, the Santa Fe Hybrid’s standard Downhill Brake Control allow you to creep down safely. The Murano doesn’t offer Downhill Brake Control.
Both the Santa Fe Hybrid and Murano have rear cross-traffic warning, but the Santa Fe Hybrid has Rear Cross-Traffic Collision-Avoidance Assist (automatically applies the brakes) to better prevent a collision when backing near traffic. The Murano’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the Santa Fe Hybrid and the Murano have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver knee airbags, side-impact head airbags, front wheel drive, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.

