For enhanced safety, the front and second-row seat shoulder belts of the Hyundai Santa Fe Hybrid have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Toyota 4Runner doesn’t offer pretensioners for its second-row seat belts.
Both the Santa Fe Hybrid and 4Runner have child safety locks to prevent children from opening the rear doors. The Santa Fe Hybrid has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The 4Runner’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
Over 200 people are killed each year when backed over by motor vehicles. The Santa Fe Hybrid Limited/Calligraphy has standard Parking Collision Avoidance Assist that uses rear sensors to monitor for objects to the rear and automatically applies the brakes to prevent a collision. The 4Runner doesn’t offer backup collision prevention brakes.
Both the Santa Fe Hybrid and 4Runner have rear cross-traffic warning, but the Santa Fe Hybrid has Rear Cross-Traffic Collision-Avoidance Assist (automatically applies the brakes) to better prevent a collision when backing near traffic. The 4Runner’s Rear Cross-Traffic Alert doesn’t automatically brake.
For better protection of the passenger compartment, the Santa Fe Hybrid uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The 4Runner uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Santa Fe Hybrid and the 4Runner have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.

